L-glutathione is the eighth of nine ingredients on the Joe's Blend box, printed as 'Glutathione (L-Glutathione)'. It is a small molecule made from three amino acids that cells build for themselves. Joe's Blend makes no whitening, lightening, glow or health claim for it.
Updated 29 September 2026. Checked against the printed box and Eurofins report AR-25-E9-005753-01.
Sources for this section: the printed Joe's Blend box, batches 140525JCA3 and 140525JCA7; Anderson, Chemico-biological interactions, 1998, PMID 9679538.
In every 21 g sachetGlutathione, written GSH, is γ-glutamylcysteinylglycine: a tripeptide built from glutamate, cysteine and glycine. Cells make it from those amino acids in two enzyme steps, and it is found in mammalian and other living cells. A 2015 paper describes the body's own glutathione as its most abundant antioxidant; that is about glutathione made in cells, not about what a sachet adds.
The box lists it as 'Glutathione', with 'L-Glutathione' in brackets. Both names on the label refer to this one ingredient.
Sources for this section: Anderson, Chemico-biological interactions, 1998, PMID 9679538; Richie and colleagues, European journal of nutrition, 2015, PMID 24791752; the printed Joe's Blend box, batches 140525JCA3 and 140525JCA7.
A US study measured glutathione in the foods on a national diet questionnaire, bought in Atlanta and prepared the usual way. Dairy products, cereals and breads were generally low; fruits and vegetables had moderate to high amounts; freshly prepared meats were relatively high. Frozen foods kept levels close to fresh, while other kinds of processing and preservation generally caused extensive losses.
That last finding is why we do not state how much glutathione survives in a dried coffee mix. We have no measurement of it in a finished Joe's Blend sachet, and the lab report we hold covers nutrition only.
Sources for this section: Jones and colleagues, Nutrition and cancer, 1992, PMID 1574445; Eurofins nutrient report AR-25-E9-005753-01.
Glutathione coffee is a coffee mix with glutathione added to its ingredient list. In Joe's Blend it is the eighth of nine ingredients, after L-theanine and before the silicon dioxide added on its own. By the label's order, which lists ingredients heaviest first, a sachet holds less glutathione than any of the seven ingredients above it; that is an inference from the order, not a measurement, because the box prints no amount.
Sources for this section: the printed Joe's Blend box, batches 140525JCA3 and 140525JCA7; Codex Alimentarius labelling standard CODEX STAN 1-1985, FAO and WHO.
A 2016 dermatology review reports that the Philippine FDA issued a public warning against intravenous glutathione for off-label uses such as skin lightening.
Joe's Blend makes no whitening, lightening or glow claim. The box prints no amount of glutathione, and we found no study that tested this coffee for any effect on skin.
Source for this section: Sonthalia and colleagues, Indian journal of dermatology, venereology and leprology, 2016, PMID 27088927.
Yes, as an oral supplement. Two randomized, placebo-controlled trials gave adults glutathione supplements at set amounts: one ran for six months in 54 non-smoking adults, the other for four weeks in 40 adults without acute or chronic disease.
Neither trial tested a coffee mix or Joe's Blend, and the box prints no glutathione amount. A result from a supplement at its own amount says nothing reliable about an unknown amount in a coffee mix, so this page describes the trials' design and does not report their results.
Sources for this section: Richie and colleagues, European journal of nutrition, 2015, PMID 24791752; Allen and colleagues, Journal of alternative and complementary medicine (New York, N.Y.), 2011, PMID 21875351; the printed Joe's Blend box, batches 140525JCA3 and 140525JCA7.
Sources for this section: the printed Joe's Blend box, batches 140525JCA3 and 140525JCA7; Eurofins nutrient report AR-25-E9-005753-01.
Four papers: what glutathione is, where it occurs in food, and two trials of oral supplements, described by design. The dermatology review cited above is in the sources list.
Overview of how cells make glutathione (γ-glutamylcysteinylglycine) from its amino acids in two enzyme steps, and how its level is regulated.
PubMed 9679538 →Measured glutathione in foods from a US diet questionnaire, bought in Atlanta and prepared as usually eaten. Dairy and cereals were low, fruit and vegetables moderate to high, fresh meats relatively high.
PubMed 1574445 →Six-month randomized, double-blind, placebo-controlled trial of oral glutathione supplements at two set amounts in 54 non-smoking adults. It did not test coffee.
PubMed 24791752 →Four-week randomized, double-blind, placebo-controlled trial of oral glutathione supplements in 40 adults without acute or chronic disease. It did not test coffee.
PubMed 21875351 →Education, not advice. Joe's Blend is coffee, not medicine, and carries no approved therapeutic claims. If you have a condition or take medication, talk to your doctor before adding anything new to your day.
Sources for this section: Anderson, Chemico-biological interactions, 1998, PMID 9679538; Jones and colleagues, Nutrition and cancer, 1992, PMID 1574445; Richie and colleagues, European journal of nutrition, 2015, PMID 24791752; Allen and colleagues, Journal of alternative and complementary medicine (New York, N.Y.), 2011, PMID 21875351.
A tripeptide, γ-glutamylcysteinylglycine, that cells make from glutamate, cysteine and glycine.
In a US food study, fruits and vegetables had moderate to high amounts and freshly prepared meats relatively high amounts, while dairy, cereals and breads were generally low.
A coffee mix with glutathione added as an ingredient. In Joe's Blend it is eighth of nine ingredients on the box, which prints no amount, and Joe's Blend makes no whitening or health claim for it.
No. Joe's Blend makes no whitening, lightening or glow claim, and we found no study that tested this coffee for any effect on skin.
The box does not print it. Glutathione is eighth of nine ingredients, so only silicon dioxide is listed after it.
Arabica with L-theanine, L-glutathione and L-carnitine, in a 21 g sachet. Hot or iced, 30 seconds.
